Cow is a Hindu sacred animal. Cow raising can be based on social, cultural, economic and religious significance from the Vedic period. About the infatuation of Kamadhenugai (Kamadhenu cow: is a mother of all cows ) of Lord Krishna (the hero of the Dwapar era) with important products like milk, curd and ghee are mentioned in Bhagwat Gita, Krishnacharitra and other Hindu scriptures. Similarly, Lord Shiva's vehicle, Nandi (bull), is also included in Hindu scriptures. It is customary for the Hindus to worship the cow as a sacred animal and to consider milk, curd (yogurt), ghee, dung and urine (panchakavyam: mixture of those ingredients) as sacred things. Therefore, killing a cow is considered a punishable offense and cow slaughter is completely forbidden in Hinduism. Nepal with more than 80% of the Hindu population considered cow as National animal and Nepalese law forbids slaughter of cattle. The milk of the local cow is considered to be the most sacred and the cow dung is used to clean houses, temples, places of worship, Tulasiko Mairo or math (at the top, Tulasi or Basil is planted) and other sacred places. From time immemorial, the Brahmins and Chhetri of the Hindu Aryans have been raising at least one cow for sanctity, while most of the rural farmers still keep local cows for milk and milk product, manure, ploughing and carts. Indigenous cow urine is also commonly used in Ayurvedic medicine for treatment of diabetes, blood pressure, asthma, psoriasis, eczema, heart attack, blockage in arteries, fits, cancer, AIDS, piles, prostrate, arthritis, migraine, thyroid, ulcer, acidity, constipation, gynecological problems (Mahajan et.al. 2020). Similarly, ghee from cow milk is used as a medicine to prevent colds (eating and body massage), aids in bone health and other health benefits like improve digestions, boost immunity, nourishes skin, nutrition supplements (vitamin A,D,E and K). In has been scientifically proven that cow urine as bio-enhancer and bio-pesticides and increase soil fertility and nitrogen content of the soil. Therefore, cow urine is used extensively in organic farming (Pradhan et al., 2018).